Liver cancer or hepatic cancer happens when the liver cells or hepatocytes start growing uncontrollably.
Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer. Liver cancers could either start in the liver or they can spread from other parts to the liver.
Liver cancer is one of the most common cancers in India, and they are more prevalent among men than women. According to cancer experts, the common risk factors associated with liver cancer include increased alcohol consumption, unsafe sex practices and sharing injection needles.
Following are the crucial symptoms that are associated with liver cancer:
Other symptoms of liver cancer may include:
The actual cause of liver cancer is unknown; however, researchers have identified a few risk factors that are associated with liver cancer:
Liver Cancer Screening: Those with Hepatitis B and C infections, alcohol-related cirrhosis, other alcohol abusers, and those who have cirrhosis as a result of hemochromatosis are all considered as high-risk individuals. They should consider regular liver cancer screening as it helps in the early detection of the disease. If liver cancer is not detected early, it is significantly more challenging to treat and manage. As liver cancers show no symptoms in their early stages, the only way to detect them early is through screening.
If liver cancer is suspected during the screening, following additional tests may be recommended for a confirmed diagnosis.
a. Blood test: Alpha-Fetoprotein (AFP) is a chemical secreted by liver tumours. Adults with increased AFP levels should consider additional tests for liver cancer, as this protein is produced in 70% of all liver malignancies. High iron levels could also indicate the presence of a tumour.
b. Imaging Tests: Ultrasound imaging is commonly recommended since it can identify tumours as small as one millimetre. These tumours are diagnosed and staged using high-resolution CT scans and contrast MRI images.
c. Biopsy: A tissue sample from the suspected area is collected and analysed under a microscope during a biopsy. This test is necessary for the definitive diagnosis of the condition.
d. Laparoscopy: Laparoscopy may be recommended in various situations, including finding tiny tumours, determining the amount of cirrhosis, collecting a biopsy, and even confirming the results from previous tests.
The treatment planning for liver cancer patients is made upon considering multiple factors, such as the patient’s age, overall health, and personal preferences, as well as the stage of the disease, tumour size, exact location of the tumour and tumour grade. The following are the treatment options available for liver cancer management:
a. Surgery: Surgery is one of the main treatment options recommended for liver cancer. Depending on the stage of the disease, there are different surgical procedures recommended by the doctor.
b. Ablation: Ablation is one of the treatment options recommended for liver cancer, and it destroys liver tumours without removing them. Ablation is usually recommended in cases where patients have small tumours or have health conditions that do not allow them to undergo surgery. Ablation is not a curative approach for liver cancer; however, it can be helpful for some patients.
c. Embolisation Therapy: Tumour cells cannot survive without oxygen and nutrients and tumour cells receive these biomolecules through the blood supply. Embolisation therapy is a treatment option for liver cancer, wherein specific chemicals are injected directly into a liver artery to restrict or limit blood flow to a tumour.
d. Radiation Therapy: This treatment method involves treating liver cancer with high-dose radiation. Radiation therapy is a non-invasive procedure that may be combined with other treatment options in order to enhance the efficacy of the overall treatment. Radiation therapy may also help in easing pain and other complications seen in patients with advanced-stage liver cancers.
e. Chemotherapy: Chemotherapy is one of the common treatment options recommended for liver cancers. The doctor may recommend chemotherapy in order to shrink the tumour before the surgery (neoadjuvant chemotherapy) or to destroy the residual cancer cells after the surgery (adjuvant chemotherapy). Chemotherapy is often combined with other treatment methods, namely radiation therapy and embolisation in order to increase the overall effectiveness of the treatment. It is also used as a part of palliative care in order to ease the symptoms caused by the disease.
f. Immunotherapy: Immunotherapy for liver cancer works by stimulating the patient’s immune system to fight against the disease. Most cancers release specific proteins that block the immune cells from attacking them. Although not a main line of treatment for liver cancer, immunotherapy can be helpful for some liver cancer patients.
g. Targeted therapy: Targeted therapy is a treatment approach used to treat cancers, and it specifically targets the genes, proteins, or tissue environment that contribute to the growth and spreading of cancers. In the case of liver cancers, targeted therapies use anti-angiogenesis drugs. These drugs halt the formation of new blood vessels and starve the tumour of oxygen and necessary nutrients.
Yes, liver cancers are treatable. The treatment plans are made depending on the stage of the disease. Early-stage liver cancers have multiple treatment options and excellent clinical outcomes, whereas advanced-stage liver cancers have relatively fewer treatment options available.
The best way to treat liver cancer is to catch it in the early stages. Any abnormal abdominal symptom that lasts for more than two weeks should be brought to a physician’s attention.
This depends upon the grade of the tumour. Not all liver cancers are fast-growing. Those that are diagnosed as high-grade grow at a faster rate than those that are diagnosed as low-grade.
High-grade or low-grade, appropriate treatment and strict follow-up regimen are important for the successful management of liver cancers.
Not all patients with fatty liver disease develop liver cancer. However, those individuals with specific types of fatty liver disease, such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are at a higher risk of developing liver cancer.
Liver transplant surgery is not a complex procedure and is generally successful. The success rate is determined by factors like the donor’s and recipient’s overall health, their ages, etc.
Immunosuppressant medicines are given to the recipient since there is a chance that the new liver or part of it will be rejected by the recipient’s body. Patients must take these medicines as recommended by the doctor. In addition, the doctor may also suggest several dietary and lifestyle adjustments. It is crucial for the patient to strictly adhere to the post-treatment regimen in order to reduce the risk of organ rejection.
Although there is no way to prevent liver cancer completely, there are a few measures that you can take to reduce the risk of liver cancer: